Duke and North Carolina are taking their much talked about and often debated men’s basketball rivalry on the road to a place its never been.

The neighboring schools are preparing for another first in a series filled with big-name players and intense finishes: playing each other in the NCAA Tournament. It seems fitting the matchup comes in the Final Four, with a berth in the championship game on the line.

It’s an intriguing script for Saturday night’s showdown in New Orleans.

Duke ran North Carolina off its own court in the teams’ first meeting this season. The Tar Heels exacted revenge by spoiling retiring Hall of Famer Mike Krzyzewski’s final home game in what appeared to be their last battle with Coach K.

A third meeting wasn’t something either wanted to talk about to start the week, not when Krzyzewski’s Blue Devils were first to earn their spot to the Big Easy and not when Hubert Davis’ Tar Heels followed a day later.

“You know what, it’s going to be an honor for us to go against whoever is the regional champion of that region,” Krzyzewski said after Saturday’s win against Arkansas to claim the West Region title. “And there’s no greater day in college basketball than when those four regional champions, four champions, get under one arena and play.”

The same was true of the Tar Heels, who continued their second-half surge by beating underdog Saint Peter’s on Sunday to win the East Region crown and reach an NCAA-record 21st Final Four despite being a No. 8 seed.

“I don’t really want to answer that right now,” UNC junior big man Armando Bacot said afterward. “It’s a good question. But I can’t answer it right now. (Team spokesman Steve Kirschner) will get mad at me.”

The fierce rivalry between programs with a combined 11 NCAA championships has long been an annual must-watch event. It’s a series featuring names like Jordan, Laettner, Hill and Jamison, among them. It also has had star power on the sideline, with Krzyzewski battling Hall of Famers like the late Dean Smith and Roy Williams before now facing a first-year coach in former UNC and NBA player Davis.

The teams had come close to this moment only once before, in 1991. That’s when both the Blue Devils and Tar Heels reached the Final Four in Indianapolis.

But the Tar Heels, with Davis as a player and Smith the coach, lost the first semifinal to a Kansas team coached by Williams. Then Duke stunned everyone by beating undefeated and reigning national champion UNLV in the second game, creating a what-could’ve-been scenario as the Blue Devils went on to beat Williams’ Jayhawks for Krzyzewski’s first of five NCAA championships.

Now it’s finally happening, but the script for Round 3 is unclear considering how wildly different the teams’ two regular-season meetings ended.

The Blue Devils won the first by 20 points in February, dominating behind a star-level performance from freshman A.J. Griffin in particular. Duke looked sharp from the outset, rolling to a 31-8 lead while looking completely unbothered by a crowd booing relentlessly in its own farewell to Krzyzewski in his final trip to Chapel Hill.

By the end, they were celebrating 3-pointers and dunks in a preening performance on the Tar Heels’ homecourt, sending fans fleeing for the exits with five minutes left.

“We have so many guys who just love the big environment,” junior Wendell Moore Jr. said afterward. “I mean, we love being the villain.”

The performance only further heightened questions about the Tar Heels’ toughness and their lack of a competitive response in lopsided losses to Tennessee, Kentucky, Miami and Wake Forest earlier in the season.

Yet their trajectory changed in the rematch to close the regular season, turning an improving team into one determined to prove its mettle in one of the game’s toughest environments. And it came amid the pomp and heightened emotion with Krzyzewski’s final game at Cameron Indoor Stadium that made it feel more like a spectacle than ever, starting with a pregame ceremony and photo with more than 90 of his former players.

The Tar Heels ignored all of it, playing instead with a fearless fire and confidence lacking in that first meeting.

Davis stuck with his five starters in a substitution-free second half that saw the Tar Heels shoot 59% and score 55 points. And by the end, the Tar Heels were celebrating a double-digit victory on “Coach K Court” and had Krzyzewski apologizing to the crowd in an awkward warm-up to the postgame ceremony in his honor.

“And I’ll tell you,” he said, “this season isn’t over, all right?”

It seems he was talking about this year’s rivalry, too.