TOKYO — Osaka issued a coronavirus alert, urging the residents to stay home as much as possible until mid-December because of a resurgence of the infections and hospitalizations.

“Our medical systems are in an emergency,” Osaka Gov. Hirofumi Yoshimura said. “We have to act now, or we won’t be able to save lives that can be saved.”

Osaka reported 386 new cases Thursday for a total of 21,404 and 341 deaths. With overcrowding hospitals, some patients were sent to neighboring areas for treatment.

Infections have been rising, including the Tokyo region, Aichi, Hokkaido and Osaka. Those areas have issued requests for bars to close early in exchange for compensation.

Nationwide, Japan has 153,000 confirmed cases and more than 2,200 deaths, according to the health ministry.