A pregnant woman was driving in the HOV lane near Dallas.
NEW YORK – Pfizer said on November 9 that early results from its coronavirus vaccine suggest the shots may be a surprisingly robust 90% effective at preventing COVID-19, putting the company on track to apply later this month for emergency-use approval from the Food and Drug Administration.
The announcement, less than a week after an election seen as a referendum on President Donald Trump's handling of the crisis, was a rare and major piece of encouraging news lately in the battle against the scourge that has killed more than 1.2 million people worldwide, including almost a quarter-million in the United States alone.
"We're in a position potentially to be able to offer some hope," Dr. Bill Gruber, Pfizer's senior vice president of clinical development, told The Associated Press. "We're very encouraged."
Dr. Anthony Fauci, the U.S. government's top-infectious disease expert, said the results suggesting 90% effectiveness are "just extraordinary," adding: "Not very many people expected it would be as high as that."
"It's going to have a major impact on everything we do with respect to COVID," Fauci said as Pfizer appeared to take the lead in the all-out global race by pharmaceutical companies and various countries to develop a well-tested vaccine against the virus. Greek-born Pfizer Chairman and CEO Albert Bourla said on CNBC that the election was always an artificial deadline and that the data was going to be ready when it was ready. The independent data monitors met on November 8, analyzing the COVID-19 test results so far and notifying Pfizer.
"I am very happy," Bourla said, "but at the same time, sometimes I have tears in my eyes when I realize that this is the end of nine months, day-and-night work of so many people and how many people, billions, invested hopes on this."
He added: "I never thought it would be 90%."
Bourla was born in Thessaloniki and earned his doctorate in the biotechnology of reproduction at Aristotle University of Thessaloniki's Veterinary School.
Scientists have warned for months that any COVID-19 shot may be only as good as flu vaccines, which are about 50% effective and require yearly immunizations. Earlier this year, Fauci said he would be happy with a COVID-19 vaccine that was 60% effective.
Pfizer opted not to join the Trump administration's Operation Warp Speed, which helped a half-dozen drugmakers accelerate their vaccine testing and helped fund the work. Instead, Pfizer funded all its testing and manufacturing costs itself. The company said it has invested billions of dollars.
The president's boasts that a vaccine could be ready before Election Day raised fears that the Trump administration might pressure regulators and scientists to cut corners for political gain. After the first presidential debate, Bourla told his employees he was disappointed their work was being dragged into political debates and pledged the company was "moving at the speed of science."
The shots, made by Pfizer and its German partner BioNTech, are among 10 possible vaccine candidates in late-stage testing around the world — four of them so far in huge studies in the U.S. Another U.S. company, Moderna Inc., also hopes to file an application with the FDA this month.
Volunteers in the final-stage studies, and the researchers, don't know who received the real vaccine or a dummy shot. But a week after their second dose, Pfizer's study began counting the number who developed COVID-19 symptoms and were confirmed to have the coronavirus.
Because the Pfizer study has not ended, Gruber could not say how many in each group had infections. But the math suggests that almost all the infections counted so far had to have occurred in people who got the dummy shots.
Pfizer does not plan to stop its study until it records 164 infections among all the volunteers, a number that the FDA has agreed is enough to tell how well the vaccine is working. The agency has made clear that any vaccine must be at least 50% effective.
No participant so far has become severely ill, Gruber said. He could not provide a breakdown of how many of the infections had occurred in older people, who are at highest risk from COVID-19.
Participants were tested only if they developed symptoms, leaving unanswered whether vaccinated people could get infected but show no symptoms and unknowingly spread the virus.
Fauci said that the Pfizer vaccine and virtually all others in testing target the spike protein the coronavirus uses to infect cells, so the latest results validate that approach.
Public Citizen, the consumer advocacy group, called the release of the preliminary and incomplete data "bad science" and said that any enthusiasm over the results "must be tempered" until they are reviewed by the FDA and its independent experts.
"Crucial information absent from the companies' announcement is any evidence that the vaccine prevents serious COVID-19 cases or reduces hospitalizations and deaths due to the disease," the organization said.
FDA has told companies they must track half their participants for side effects for at least two months, the period when problems typically crop up. Pfizer expects to reach that milestone later this month.
Because the pandemic is still raging, manufacturers hope to get permission from governments around the world for emergency use of their vaccines while additional testing continues. That would allow them to get their vaccines to market faster, but it also raises safety concerns.
Material from the Associated Press was used in this report.
A pregnant woman was driving in the HOV lane near Dallas.
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